Seeing participation of researchers, creative industries, and teaching material providers, ELIXIER is a multidisciplinary research project that explores and validates demonstrators of a new generation of connected smart labs allowing tutor-supported end-to-end learning and working in augmented mixed-reality experimental environments. The overall goal of the project is to design a user-friendly and effective dialog between the learners, the experiment, and the digital learning material. Pursuing a systemic approach, a major result of the project will be the experimentation platform »Seamless Smart Lab (S2L)«, a web-based solution that supports a seamless continuation of individual experimental experiences made in real-world settings with interactive digital material and vice versa. By closely linking learning experiences made in the real and the virtual world, ELIXIER opens up new possibilities of close-to-practice and cumulative lifelong learning.